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Assuming an arbitrary threshold of 99% of the fitted saturated level, it corresponded to B 12 = 488 pg/mL (Figure 2)

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Unlike GLP-1 agonists such as semaglutide or tirzepatide, which work primarily through appetite suppression, AOD-9604 directly enhances fat metabolism at the cellular level through beta-3 adrenergic receptor modulation

This approach mirrors dosing strategies used for other peptides with 1216 hour half-lives, though published 5-amino-1mq pharmacokinetic data in humans remains limited

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