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Clinical therapy of targeting ferroptosis in human diseases Numerous preclinical studies have demonstrated that iron acts as a potent pro-oxidant, contributing to the development and progression of tumors, central nervous system diseases, metabolic diseases, autoimmune diseases, and cardiovascular diseases through the production of highly reactive and cytotoxic free radicals

E., MacDonald A

Intramuscular injections provide a convenient alternative for maintenance therapy schedules

Gebreslassie HG

Biochemistry of lipids, lipoproteins and membranes

3.2 Destruction of periodontal soft tissues The integrity and function of PDLFs, essential for softtissue homeostasis, are compromised by ferroptosis through a twofold assault on collagen: synthesis is reduced because PDLF viability and activity are impaired, while degradation is accelerated by ferroptosisassociated ROS and proinflammatory mediators ( in vitro primary cell models, indicate that ferroptosis in periodontal ligament fibroblasts serves as an active driver of soft tissue destruction