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Intense exercise increases the fragility of RBCs

The average molecular weights of TP-1 to TP-6 were 5.0 10 5 Da, 2.0 10 5 Da, 3.0 10 4 Da, 1.0 10 5 Da, 1.0 10 4 Da, and 4.0 10 3 Da, respectively

Pharmacological inhibition of p-ERK upstream signal with the FDA-approved drug dabrafenib 32 reduced noise-induced GSDMD-N and 4HNE levels (Fig