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Moreover, the secretion of IFN by CD8 + T cells can effectively coordinate the suppression of SLC7A11 expression, thereby activating the ferroptosis pathway, which enhances the antitumor immunotherapeutic effect of anti-PD-L1 antibodies [144]

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The specific localization along with intense expression of these enzymes in renal carcinoma has led to the design of kidney-selective prodrugs that bypass earlier steps of the mercapturic acid pathway (GST, GT, and peptidase): these compounds include S -(guanin-6-yl)-L-cysteine (Elfarra et al., 1995), S -(6-Purinyl)-L-cysteine (Hwang and Elfarra, 1991

NIEHS P42 ES004699 to BH and a WCMC Pilot Project from NIH U24 DK097154 to FS and BH

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