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For many individuals, oral B12 supplements are ineffective due to such underlying conditions as: Pernicious anemia : People with this condition lack intrinsic factor, a protein required for B12 absorption in the small intestine

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2.12.4 Quenching of fluorescence A very promising spectroscopic technique for evaluation of solvent accessibility of aromatic residues in a protein involves the quenching of their intrinsic fluorescence by the addition of various low molecular weight agents (Lehrer, 1971

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The peptide essentially reprograms cellular behavior toward more youthful function, explaining why anti-aging applications have generated significant interest