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doi: 10.3390/toxins13020171
4.5 Ferrostatin-1 Fer-1 acts as a lipophilic free radical scavenger due to its redox cycling activity (Doll and Conrad 2017), and alleviates ferroptosis by inhibiting lipid peroxidation and preventing GPX4 deletion or GSH depletion (Zilka et al., 2017
Pate et al
AITD frequently coexists with features of metabolic syndrome, including obesity, insulin resistance, dyslipidemia, and metabolic dysfunction-associated steatotic liver disease (MASLD), reflecting the bidirectional interplay between immune dysregulation and metabolic stress [3,4]

For example, impaired mitochondrial metabolism in NAFLD impairs FA oxidation processes (e.g., mitochondrial beta-oxidation) and induces elevated DNL, which ultimately continues to drive NAFLD progression in the form of lipid accumulation [39, 40]

Furthermore, the supposed benefits of aspirin in at-risk individuals must be weighed against the established health risks of the drug, including an increased risk of GI bleeding, hemorrhagic stroke, and brain bleeding
