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GLP- 1 receptor agonism has not been thoroughly studied, but it has been demonstrated in certain cell lines to activate additional G-protein subunits and alternative downstream signaling pathways [60,61,62] GIP Receptor Signaling The mature 42 amino acid GIP attaches itself to the b cell surface and activates its cognate receptor, the GIP receptor

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Reduced L-glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine and glycine that occurs in every human cell

In the chronic stress model caused by MS, depression-like behaviours have been observed with increased corticosterone levels, decreased ACTH, and reduced serum antioxidant capacity 42,43

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This review integrates recent findings to demonstrate how cuproptosis-based strategies can circumvent resistance, thereby laying the groundwork for the development of novel therapeutic approaches