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Description
Glutathione S-transferase P1 and DNA polymorphisms influence response to chemotherapy and prognosis of bone tumors
Treated mice show a 15%20% increase in basal metabolic rate and elevated energy expenditure, with effects positively correlated with NNMT inhibition
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(ii) glutamine-derived aspartate supports eukaryotic translation initiation factor 5 A (EIF5a) hypusination and HIF1 translation, promoting metabolic changes, i.e., enhanced glycolysis, in tumor-associated macrophages, which is correlated to advanced tumors [180]
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Journal of Thoracic and Cardiovascular Surgery 161(2):448-454, 2021
