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4.2.4.4 Enzyme-responsive nanoparticles Principally, enzyme-responsive nanoparticles are sensitive to specific enzyme activity that enables high sensitivity for the specific substrates, as expected to modulate a drug release via dissolution and/or degradation of the matrix (Guo et al., 2012

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In this study, we investigated the molecular recognition mechanisms of two clinically approved drugs: Macimorelin (used for diagnosing adult growth hormone deficiency) and Anamorelin (approved in Japan for cancer cachexia)