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Daten aus vorklinischen und klinischen Studien sowie Einzelflle, die der Akd berichtet wurden, sprechen fr einen Zusammenhang zwischen der Gabe des Anti-IL-17A-Antikrpers Secukinumab (Cosentyx) und der Verschlechterung einer vorbestehenden chronisch-entzndlichen Darmerkrankung (CED) und mglicherweise auch der Erstmanifestation

A phase 1 trial (synonymous with dose-escalation or human pharmacology studies) is the first instance in which a new investigational agent is studied in humans

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