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[DOI] [PubMed] [Google Scholar] 41.Sekhar R.V., McKay S.V., Patel S.G., Guthikonda A.P., Reddy V.T., Balasubramanyam A., Jahoor F

In recent years, various tactics have been applied to assist drugs to cross the BBB including osmotic disruption of the BBB and chem

However, the full benefits can accumulate over time with regular injections

304 Fibrotic scar is a common component of MS mature lesions

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The rationale for our hypothesis is that the electrophilicity of EA represented by the ,-unsaturated ketone moiety facilitates an irreversible chemical reaction with the highly nucleophilic Cys314 residue in the catalytic triad of FXIIIa, which is the only transglutaminase among all clotting factors, resulting in its inhibition [16, 17]
