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Therefore, there has been an emerging interest in assessing NNMT as a potential therapeutic target and discovering NNMT inhibitors over the past 5 years

While higher doses (particularly 54 mg) showed some increase in gastrointestinal-related events, these remained mild to moderate in severity and did not result in treatment discontinuation

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Although mechanisms have yet to be established, vascular disease, ischemia, and cerebral cortex atrophy as indicated from CT scans, have been implicated as contributing factors