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Enhancing SIRT1 activity could serve as a potential therapeutic strategy for mitigating ferroptosis-associated diseases by reducing inflammation, preserving antioxidant defenses, and regulating lipid metabolism

[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Blindauer CA, Harvey I, Bunyan KE, Stewart AJ, Sleep D, Harrison DJ, et al

Such results may also be confounded by effects of UA-lowering medication and dietary changes

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Consequently, the antioxidant enzymes produced may be inadequate in clearing the excessive ROS, resulting in continuous oxidative damage to intestinal cells

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