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It is known to exacerbate inflammation and redox imbalances (251) by triggering the NLR family pyrin domain containing 3 (NLRP3) inflammasome (251), increasing the release of inflammatory cytokines such as IL-1 and IL-18 (376)

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In addition, the biophysical properties of mucus worsen under the influence of oxidation arising from airway neutrophilic inflammation or environmental exposure leading to increased mucin polymer crosslinks and stiffening of the airway mucus gels [89]

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doi: 10.1016/j.jtemb.2020.126558 14