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Figure 3 4.2 Necroptosis promotes antigen cross-presentation and durable immunity Restoration of necroptotic signaling in melanoma, either through epigenetic modifier inhibitors to reverse RIPK3/MLKL silencing or direct small-molecule activation of the RIPK1/RIPK3/MLKL axis, enhances tumor cell immunogenicity by amplifying DAMP release and antigen cross-presentation, a phenomenon that has been validated in both in vitro melanoma cell models and in vivo syngeneic melanoma mouse models (106)

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In addition to the typical structural fold, the threefold pseudo-symmetrical, six transmembrane -helices surrounding the central transport cavity, the analysis revealed that A39 contains an extra mitochondrial matrix loop between transmembrane domain 1 and 2 with a low structural prediction confidence score (Fig

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