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Potential therapeutic interventions, such as folinic acid and antioxidant therapy, have been identified as promising strategies to counteract MTX-induced hepatotoxicity (Created by BioRender.com).

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Using these validated tools, we analyzed serum samples from rats and monkeys injected subcutaneously with GX-G3 (1, 3 or 10 mg/kg once a week for 4 weeks followed by a 4-week recovery period) to determine immunogenicity response and toxicokinetic parameters with serum concentration of GX-G3

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