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Inhibition of extracellular signal-regulated kinase downregulates claudin-2 expression and alters paracellular permeability in mouse rectum CMT93-II cells

These differences in GST type and multiplicity, as well as residue changes that impact the secondary and tertiary structure of the cat and dog GST proteins, affect substrate selectivity and catalytic efficiency

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15 March 2025 A Correction to this paper has been published: Abbreviations AMPK: AMP-activated protein kinase GHRH: Growth hormone releasing hormone CNS: Central nervous system GHRHR: GHRH-Receptor GH: Growth hormone GHR: Growth hormone receptor GHS-R1a: GH-secretagogue receptor 1a icv: Intracerebroventricular IGF-1: Insulin-like growth factor 1 IGFBP-3: Insulin-like growth factor binding protein 3 LEPR: Leptin receptor NPY: Neuropeptide Y OX-A: orexin-A cAMP-PKA: Cyclic AMP Protein Kinase A MAPK: Mitogen-activated protein kinase GPCR: G protein-coupled receptor SST: Somatostatin ARC: Arcuate Nucleus of the hypothalamus PeN: Periventricular Nucleus of the hypothalamus Pit-1: Pituitary transcription factor 1 PVH: Paraventricular hypothalamus of the hypothalamus ME: Median Eminence VMH: Ventromedial nucleus of the hypothalamus References Schally AV, Zhang X, Cai R, Hare JM, Granata R, Bartoli M

Such drugs therefore need to be administered at more frequent dosing intervals