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The activation of the Na + /H + exchanger (NHE), as an attempt to correct acidosis, leads to an accumulation of intracellular Na + , which in turn inhibits Ca 2+ extrusion through the Na + /Ca 2+ exchanger (NCX), thereby contributing to calcium overload [163]

Aeschlimann G

Kidney Dysfunction: High doses over a prolonged period could potentially strain the kidneys, especially in individuals with pre-existing kidney conditions

Liposomal glutathione or sublingual forms may provide better absorption compared to standard oral supplements

doi: 10.3233/JPD-181474

This validates the presence of functional GLY III enzyme in rice that can carry out MG detoxification following a shorter GSH-independent route in contrast to the conventional GSH-dependent two step glyoxalase I/II pathway