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Effects on Blood Flow and Angiogenesis Another proposed mechanism involves the peptides influence on angiogenesis, the formation of new blood vessels

Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism

10.1080/10739680590960962 [DOI] [PubMed] [Google Scholar] Nikolaev, S

Administration: Intravenously, under professional medical supervision

Regulatory agencies require extensive clinical evidence before approval, and the absence of such data means safety and effectiveness remain uncertain

Its interaction with the VEGFR2-Akt-eNOS signalling pathway is one proposed mechanism currently under investigation