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CRP is synthesized in smooth muscle cells of atherosclerotic lesions with active disease, foam cells, macrophages, lymphocytes, monocytes, and endothelial cells within the atherosclerotic plaque (166170)

Proc Natl Acad Sci USA 1990;87:40637

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The cardiovascular and respiratory side effects include chest pain, tachycardia (increased heart rate), heart palpitations, low blood pressure, and chest tightness, cough with or without production of pink frothy sputum, wheezing and difficulty breathing

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