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doi: 10.1016/j.canlet.2008.02.029

(2005) The SH2-domain-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading

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The histological and ultrastructural findings are identical to those of the CaLS, and so some authors propose to include freckles and CaLS in the same diagnostic criterion.41 We also support this proposal, particularly if we remember that Legius syndrome meets 2 criteria in 48% of cases and presence of both criteria does not increase the specificity of diagnosis.24 Freckles can appear in other genetic diseases included in the differential diagnosis (Table 2), particularly in cases in which they coexist with CaLS

Here we show in humans and in mouse models that cell volume changes play a central role in inflammasome activation upon macrophage exposure to MSU/CPP crystals

Dry, flaky skin: Hydration is key for smoother, softer skin