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MitoQ has been successfully used in humans, showing a reduced placental MDA and lower levels of placental lipid peroxidation

doi: 10.1016/j.redox.2023.102861 [DOI] [PMC free article] [PubMed] [Google Scholar] 148.Larsen EL, Kjr LK, Lundby-Christensen L, et al

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In mammals, cGAS catalytic activity is triggered by interaction with dsDNA, when combined with dsDNA, cGAS dimer assembly on dsDNA, causes cGAS enzyme activation and 2 3 cyclic GMP-AMP (cGAMP) synthesis (143)

This can easily explain that A deposits themselves do not correlate with early signs of neurodegeneration or impaired cognition
