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Necroptosis and pyroptosis are characterized by the formation of plasma membrane pores via caspase-1, which leads to the pro-inflammatory cytokines release and cell lysis, and thus controls the inflammatory response

Multiple clinical studies have shown that integrating metabolic modulation with immunotherapy, chemotherapy, or targeted agents can significantly improve outcomes (Table 2)

This subsequently leads to a reduction in podocyte apoptosis and ultimately mitigates the kidney injury caused by diabetic nephropathy

This effect is achieved by target cell apoptosis, antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity, with the effect lasting up to 6 months [47]

The aim of this strategy is to reduce the bacterial burden (as in this phase it is virtually impossible to eradicate the pathogen) and, thus, reduce the inflammatory response that leads to structural lung damage and loss of function,4,78 avoiding the cumbersome and toxic iatrogenic effects associated to oral or intravenous route.79 It seems that this strategy may reduce the frequency and severity of respiratory exacerbations and the decline in lung function.80,81 One trial conducted in 2000 randomly assigned 74 patients with non-CF BE and P