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Consensus sequence One approach that has been taken is to design vaccine antigens that are enriched for conserved T and B-cell epitopes either as a consensus sequence (which is the closest natural circulating sequence to a bioinformatically calculated consensus) or as a string of epitopes taken out of their natural context within the viral protein (Fig

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For the combination of inhibitors of MEK and PI3K, the model predicted lower pERK consistent with experiments, but the lowered pAkt predicted by the model was lower than the data from experiments