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For example, mutations of BRAF and NRAS are the 2 most common in melanoma tumors: 40% to 60% for BRAF , and 15% to 20% for NRAS

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This motif is present in the Na + -driven hOCTN1 and mOCTN3, but notably absent in OCTs and OATs, suggesting a possible OCTN-specific role of this motif