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The incomplete reduction of O 2 during respiration within the ETC can trigger the production of ROS, a process that is catalyzed by iron ions

doi: 10.1353/hpu.2011.0166

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Pernicious anemia ICD-9-CM: 281.0 Approximate Flag - The approximate mapping means this ICD-10 code does not have an exact ICD-9 equivalent

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By comparison, when the term genotype refers to one G6PD allele versus others (item 3 above) the differences are rather marginal, especially as it is now clear that, even with G6PD A-, hitherto often regarded as a mild variant, the clinical manifestation can be anything but mild (Pamba et al , 2012)