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This is proposed to be mediated by TRX1 oxidation by hydrogen peroxide which causes dissociation of ASK1 thereby triggering anti-apoptotic factors via downstream activation of MAPK kinase MKK3/MKK6/p38 and MKK4/MKK7/JNK pathways (Wagner et al

10.1128/AAC.01403-10 [DOI] [PMC free article] [PubMed] [Google Scholar] Saint-Criq V., Ruffin M., Rebeyrol C., Guillot L., Jacquot J., Clement A., et al