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To assess this potential, we treated SCD erythroblasts with DNA methylation inhibitor 5-Azacytidine (5AZA) and found global and CBS locus DNA demethylation along with CBS induction (Supplementary Fig

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In turn, this mechanistic effect might contribute to an environment that favors enhanced nutrient and oxygen delivery through vascularization, complementing the peptides other reported influences on cell survival and proliferation

This alternative is quite convenient since it is relatively easy and quick for patients to do at any time they wish to, without requiring them to leave the comfort of their own home