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These gaps underscore the demand for next-generation, mechanism-driven approaches that can modify disease biology across genetic, molecular, metabolic, and microenvironmental domains (Zhao et al., 2024

Additional information Competing interests The authors declare they have no competing interests

It also improves the tendon-to-bone integration and counteracts the healing impairment due to corticosteroid use

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Bone marrow mesenchymal stem cells (BM-MSCs), also known as BM mesenchymal stromal cells, are multipotent mesenchymal precursor cells that have many favorable characteristics for regenerative therapy, including anti-inflammatory and immune-modulatory properties (182, 183)

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