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Silybin and other related flavonolignans may act as ATs, although there is now evidence that they also act on the cellular membrane of hepatocytes, inhibiting the absorption of toxins (Dewick, 2009)

Resveratrol, the main active component of Polygonum cuspidatum [100], is a natural activator of SIRT1 and an antioxidant [101, 102]

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Cited Date: 2026-07-03 Product: Journal: Zagazig Veterinary Journal Author: Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University 44511

Activation of PGC-1 in muscle cells not only promotes mitochondrial biogenesis and enhances metabolic efficiency but also influences the expression of FNDC5, thereby controlling irisin release [60,89]