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For instance, the loss of SWI/SNF function can lead to the physical silencing of key tumor suppressor pathways, thereby enhancing therapeutic resistance [55]

Altogether, all the factors listed above contribute to the metabolic heterogeneity of the stored RBC beyond the chronological age of the unit (i.e., the days elapsed since donation), suggesting a more relevant role for the metabolic age of the unit as a critical predictor of transfusion outcomes in the future [216]

Mutation-specific therapies aim to correct the underlying mutation through the use of a gene-editing platform or replace the faulty mitochondrial DNA-encoded protein by delivering the wild-type gene using a suitable vector

Together, they work to enhance overall skin health, providing a robust defense against oxidative stress while promoting rejuvenation

10.1016/j.bbr.2012.07.04510.1016/j.pbb.2012.02.014 32 ZhangL

A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer