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PLoS One 10:e0123454 Tkalcevic VI, Cuzic S, Brajsa K et al (2007) Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression

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Study Design (design, primary outcome, participants, etc) Design: Double-blind, double-dummy, 22 factorial RCT at 11 UK hospitals from 12/2005 to 11/2008 By double dummy, we mean that there was a sham placebo for each of the study drugs Primary Outcome Change in the percent of the hemithorax taken up by effusion on CXR at day 7 compared to day 1 Key secondary outcomes: Referral for surgery Hospital LOS All cause 3 month and 12 month mortality AEs Participants Inclusion: Clinical evidence of infection (assessed by recruiting MD

Jones D, Carlson JL, Mody VC, Cai J, Lynn M, Sternberg P

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Since the NP is a confined, avascular space, the injected factor may be retained for long time