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However, we are only now starting to grasp many of these microorganisms functions in human health and development ( The human microbiota comprises more than 100 trillion microbial species, within which bacteria, fungi, viruses, and protozoa are distinguished ( Most studies prove that the balance between the microbial species in the gut microbiota is fundamental for maintaining the bodys homeostasis ( In the past decade, CVDs have emerged as the leading cause of death worldwide, taking an estimated 17.9 million lives yearly ( The purpose of the present review is to explore the role of the gut microbiota concerning the development of CVD, focusing on our previous works ( 2 Gut microbiota ecology and its implication on cardiovascular diseases 2.1 Bacterial microbiota Emerging evidence suggests that the gut microbiota may be an essential contributor to the development of CVDs, such as atherosclerosis, hypertension, coronary artery disease, and stroke