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Clinical data provide some support for the efficacy of NAC in preventing relapse and normalizing glutamate homeostasis

10.1074/jbc.R117.791962 164 PhullA

And here we should also mention that the studies don't fully agree on how long it lasts

In the Neelakantan study, diet-induced obese (DIO) C57BL/6 mice were treated with NNMT inhibitors including 5-Amino-1MQ analogues

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Scientific Reports , 12