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A final proof by BPC 157 therapy (not achievable by dopamine agents) is the counteraction of the dopamine receptor supersensitivity (and thereby counteraction of amphetamine over-activity in haloperidol pretreated mice) as a general phenomenon given that counteraction confirms the resolution of the otherwise determining issue of decreased dopamine synthesis [152,164]

Initially, studying desensitization was made possible by using experimental models endogenously expressing OR such as brain membranes, rabbit cerebellum or cell lines (NG 108-15, SH-SY5Y, SK-N-SH, SK-N-BE)

These are reversible upon discontinuation

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Then, 250 l sample solution (580 and 5800 M in sterile water) and 2.25 ml of culture medium were added into each well in triplicates

& Daly, A