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In the nigrostriatal tract system, dopamine undergoes autooxidation or oxidative deamination by monoamine oxidase-B, both of which aggravates with age, leading to increased production of peroxides and hydroxyl radicals 41

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However, these guidelines largely focused on hydrochlorothiazide, not chlorthalidone or other thiazide-like drugs like indapamide (Stafford et al., 2010

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