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Ipamorelin and Hexarelin instead act on the ghrelin receptor (GHS-R1a) in the pituitary and hypothalamus, triggering GH release through a separate pathway

Mutagenic potential can be investigated in the Ames test in the presence or absence of a metabolizing system (e.g., Aroclor 1254-induced rat liver S9 fraction) to identify pro-mutagens as well as directly acting mutagens

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