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The two active forms are produced on separate metabolic pathways and perform completely different functions

Some high risk groups for vitamin B12 deficiency include: elderly people- often stomach acid production decreases with age individuals who have had intestinal surgery such as weight loss surgery or laparoscopies individuals with GI issues including celiac disease, IBD, IBS (MOST OF YOU!!!) those following a vegetarian or vegan diet- due to the lack of animal protein eaten (one of the main sources of B12) individuals with pernicious anemia- do not make intrinsic factor Notice how a fair amount of the high risk individuals are those with some sort of intestinal issue

In other words, the schedule is a sensible default that a clinician can adjust, not a fixed rule you should try to bend on your own

[DOI] [PubMed] [Google Scholar] 9.Hall J

Mood swings that creep in without warning

doi:10.1016/j.thromres.2013.07.019 Sconce E, Avery P, Wynne H, Kamali F