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Ubiquitin-mediated mitophagy Parkin is a cytosolic E3 ubiquitin ligase, and mutations in Parkin genes are responsible for the pathogenesis of autosomal recessive parkinsonism (ARP) [164, 165]

Additionally, dyslipidemia, hypertension, and other factors are recognized as potential drivers of MetS pathogenesis (Tilg et al., 2020)

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Clinical trials measuring body composition found that fat mass reductions occurred without corresponding increases in lean tissue mass, confirming the absence of anabolic muscle-building effects

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All protocols discussed require physician oversight and informed consent