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In addition, melasma is more predominant in the female gender and it has been reported that females are 910 times more prone to melasma disorder in comparison to males (Majid and Aleem, 2021)

Horsley targeted the P1 master regulator region 3642 determined by Doherty et al

Folkman, J

J., Sarkar B

doi: 10.3389/fnagi.2026.1729015 Received 20 October 2025 Revised 30 January 2026 Accepted 09 February 2026 Published 27 February 2026 Volume 18 - 2026 Edited by Ashok Kumar, University of Florida, United States Reviewed by Jessica N

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