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IV treatment is most useful when there is a specific clinical reason to bypass the digestive system

Methylcobalamin and cyanocobalamin are both forms of vitamin B12 that help prevent B12 deficiency, but they differ in structure and source

The goal is support without adding friction to an already sensitive system

Conversely, a few studies reported high levels of vitamin B12 in the blood of patients with a worse COVID-19 outcome 48,49 potentially due to cytolysis leading to the release of intracellular B12 into the plasma and disrupted B12 clearance by the liver, which is often affected in these patients 50

AdoCbl form is stored in the cellular tissues, particularly in the mitochondria

Different absorption methods used for these B12 forms lead to delayed testing outcomes