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Therefore, the PFOS-mediated apoptosis started with ERK1/2 activation, which was followed by ER stress and autophagy induction

In some cases, additional investigations such as hormonal profiling, genetic testing, or imaging studies may be necessary to identify underlying conditions or abnormalities that affect fertility

This releases cytochrome C from mitochondria and forms apoptosomal complexes, and ultimately, activates the apoptotic mechanism in cells by activating caspase cascades (34)
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doi: 10.1146/annurev-food-030212-182623
