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On the one hand, the occurrence of MOMP will lead to the release of apoptosis-related proteins into the cytoplasm, thus causing the opening of the mitochondrial permeability transition pore, which in turn results in the disruption of mitochondrial respiration, matrix swelling, and rupture of the mitochondrial outer membrane, thereby inducing apoptosis

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Furthermore, curcumin treatment led to the reduction in ROS and lipid peroxidation in cerebellum as well as improvement of reduced glutathione and glutathione-S-transferase in cerebrum which showed the neuroprotective behavior of curcumin on Al-induced neurodegenerative and behavioral disorders in rats [105]

Ketamine has also been used as an anesthetic in veterinary medicine and human anesthesia

Determining how the GPCRs in the adipose tissue sense glucose will offer new and better therapeutic approaches for treating metabolic diseases including diabetes and obesity