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Using biotin-probe profiling, gene knockout/knock-in models, UPLC-MS metabolomics and computational simulations, the researchers demonstrated that: CD36 binds multiple PROTAC molecules (including SIM1-Me, MZ1 and ARV-110) as well as large-molecule drugs such as rapamycin, navitoclax, birinapant, tubacin and doxorubicin, thereby promoting their cellular uptake and pharmacological activity

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However, in principle, isotopologue pattern similarity calculation using IsoNet is highly similar to conventional dynamic programming

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