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[10] Selected BPC-157 studies have reported pro-angiogenesis-associated readouts in preclinical and cell-based systems, with published evidence more directly reporting VEGFR2-associated signalingincluding VEGFR2 expression, internalization, and downstream VEGFR2-Akt-eNOS pathway activationrather than broadly demonstrating upregulated VEGF transcription or secretion across all models

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Environmental pollutants, UV radiation, and poor diet all contribute to this burden

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CMAJ 171: 251-259