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The difference between the Ca 2+ concentration outside the cell, within the interstitial fluids, is on the order of 12,000 times that of the free intracellular concentration
At the same time, glutaminolysis generates ammonia, essential for maintaining renal pH and cellular and systemic homeostasis, and is released from glutamine breakdown [46]
, MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer
Petscavage-Thomas JM, Walker EA, Bernard SA, Bennett J
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