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doi: 10.3233/jad-2005-7206
The drug-binding sites of P-glycoprotein are generally found in the 2 hydrophobic membrane-spanning domains, which together also form the drug translocation pathway through the membrane (Fig
Therefore, screening for lead compounds able to activate this essential enzyme might protect neuronal cells from damage and slow the disease progression
Furthermore, moderate ROS levels can promote survival mechanisms such as autophagy or mitophagy, eliminating damaged mitochondria and enabling cellular regeneration (Baldelli et al
Inflammatory conditions : Clinical research shows hydrogen water reducing inflammatory markers in conditions like rheumatoid arthritis and inflammatory bowel disease, with mechanisms involving the suppression of pro-inflammatory signaling pathways
10.1146/annurev-arplant-042110-103819 Ann
