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The interface with the second largest buried surface area in the Tyk2 crystal lattice did place the C- and N-termini in close enough proximity to be linked by the interdomain linker, and this interface was investigated in detail and mutational data did support the biological significance of this interaction surface

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This represents a modulatory rather than direct agonist/antagonist profile that distinguishes it from conventional dopaminergic drugs

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Many researchers find that by the time they reach higher doses, the GI response has settled considerably