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Peroxidase (POD) and catalase are two of the most important of these ( 3+ and Cu 2+ )

However, the supplementation significantly blunted this deleterious effect of HM induced cardiac damage in dose dependent manner by EECGLs

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Glutathione Reduced glutathione (L--glutamyl-L-cysteinylglycine) is the most prevalent cellular thiol and the most abundant low molecular weight peptide present in all cells [71] (Figure 4)

Attribution to specific NOX sources benefits from O 2 readouts by DHE-HPLC (especially for NOX2) and from compartment-targeted, genetically encoded H 2 O 2 sensors such as HyPer variants that can be directed to the plasma membrane, endosomes, or nucleus to resolve isoform- and location-specific signaling with appropriate pharmacologic and genetic controls (Cipriano et al

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