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The autophagy pathway also plays a complex role in tumor immunity and therapy [182]

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Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation

These results suggest that HT treatment can activate the Nrf2 pathway in the progress of improving intestinal oxidative damage

Furthermore, novel therapeutic approaches have been developed to target signaling pathways in OCSCs (108)

34 Fenton reaction and lipid peroxidation in hepatotoxicity According to a more recent review by Dixon and Stockwell, 35 there are three essential hallmarks that define ferroptosis: the loss of lipid peroxide repair capacity by the phospholipid hydroperoxidase GPx4, the availability of redox-active iron, and the oxidation of PUFA-containing phospholipids . Although the term ferroptosis is new, the process of iron-dependent lipid peroxidation (LPO) as a mechanism of cell death in the liver has been recognized for 60 years